Research

Cardiac Imaging HiP-CT Synchrotron X-ray Tomography During my postdoc at the European Synchrotron Radiation Facility (ESRF), I used Hierarchical Phase-Contrast Tomography (HiP-CT) to depict the macro- to microanatomy of structurally normal and abnormal adult human hearts ex vivo. Joseph Brunet (left) and Hector Dejea (right) positioning a heart during an experiment HiP-CT allows for high-spatial-resolution, three-dimensional imaging of the heart, revealing histologic-level detail without the need for invasive sectioning or exogenous contrast agents. The study involved imaging two hearts: one from a healthy 63-year-old male and another from an 87-year-old female with a history of cardiovascular diseases. ...

Aortic Dissection Tension-Inflation Synchrotron X-ray Tomography During my PhD at École des Mines de Saint-Étienne, I worked on vascular biomechanics as part of the AArteMIS project. My research focused on identifying and quantifying the mechanisms behind vascular failure, particularly aortic dissection, to improve diagnostic and therapeutic strategies. Suture of a rabbit aortic sample on the tension-inflation device connectors To this end, I performed in situ experiments combining mechanical testing and imaging techniques. I generated in vitro dissections in porcine and rabbit aortas and visualized them using X-ray micro-tomography, both conventional and synchrotron-based. ...