Cardiac Imaging

Python Library Tractography Myocyte Orientation Cardiotensor ( ) is an open-source Python package developed to quantify 3D cardiomyocyte orientation and reconstruct continuous tractography of myoaggregates in volumetric cardiac imaging datasets. The library is designed for modern high-resolution modalities such as synchrotron tomography (HiP-CT), micro-CT, and 3D optical imaging. It supports datasets up to teravoxel scale through chunk-based and parallelized processing pipelines. Cardiotensor workflow: orientation computation with structure tensor, helical angle (HA) and intrusion angle (IA) mapping, and streamline-based tractography ...

Cardiac Imaging HiP-CT Synchrotron X-ray Tomography During my postdoc at the European Synchrotron Radiation Facility (ESRF), I used Hierarchical Phase-Contrast Tomography (HiP-CT) to depict the macro- to microanatomy of structurally normal and abnormal adult human hearts ex vivo. Joseph Brunet (left) and Hector Dejea (right) positioning a heart during an experiment (Image credit: ESRF / Stef Candé) HiP-CT allows for high-spatial-resolution, three-dimensional imaging of the heart, revealing histologic-level detail without the need for invasive sectioning or exogenous contrast agents. The study involved imaging two hearts: one from a healthy 63-year-old male and another from an 87-year-old female with a history of cardiovascular diseases. ...